Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodelling and Xbp1

A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitude of diverse stimuli throughout their lifespan. H...

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Bibliographic Details
Published in:Nat Aging
Main Authors: Corrales, Guillermo Martínez, Li, Mengjia, Svermova, Tatiana, Goncalves, Alex, Voicu, Diana, Dobson, Adam J., Southall, Tony D., Alic, Nazif
Format: Artigo
Language:Inglês
Published: 2022
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614430/
https://ncbi.nlm.nih.gov/pubmed/37118537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s43587-022-00312-x
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