A two-residue nascent strand steric gate controls synthesis of 2’-O-methyl- and 2’-O-(2-methoxyethyl)-RNA

Steric exclusion is a key element of enzyme substrate specificity, including in polymerases. Such substrate specificity restricts the enzymatic synthesis of 2’-modified nucleic acids, which are of interest in nucleic acid-based drug development. Here we describe the discovery of a two-residue, nasce...

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Veröffentlicht in:Nat Chem
Hauptverfasser: Freund, Niklas, Taylor, Alexander I., Arangundy-Franklin, Sebastian, Subramanian, Nithya, Peak-Chew, Sew-Yeu, Whitaker, Amy M., Freudenthal, Bret D., Abramov, Mikhail, Herdewijn, Piet, Holliger, Philipp
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614059/
https://ncbi.nlm.nih.gov/pubmed/36229679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-022-01050-8
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