ロード中...
A two-residue nascent strand steric gate controls synthesis of 2’-O-methyl- and 2’-O-(2-methoxyethyl)-RNA
Steric exclusion is a key element of enzyme substrate specificity, including in polymerases. Such substrate specificity restricts the enzymatic synthesis of 2’-modified nucleic acids, which are of interest in nucleic acid-based drug development. Here we describe the discovery of a two-residue, nasce...
保存先:
| 出版年: | Nat Chem |
|---|---|
| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2022
|
| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7614059/ https://ncbi.nlm.nih.gov/pubmed/36229679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-022-01050-8 |
| タグ: |
タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!
|