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Diene Incorporation by a Dehydratase Domain Variant in Modular Polyketide Synthases

Modular polyketide synthases (PKSs) are biosynthetic assembly lines that construct structurally diverse natural products with wide-ranging applications in medicine and agriculture. Various mechanisms contribute to structural diversification during PKS-mediated chain assembly, including dehydratase (...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Hobson, Christian, Jenner, Matthew, Jian, Xinyun, Griffiths, Daniel, Roberts, Douglas M., Rey-Carrizo, Matias, Challis, Gregory L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2022
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613849/
https://ncbi.nlm.nih.gov/pubmed/36109649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-022-01127-y
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