EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation

Cell death signalling pathways contribute to tissue homeostasis and provide innate protection from infection. Adaptor proteins such as RIPK1, RIPK3, TRIF and ZBP1/DAI that contain receptor-interacting protein (RIP) homotypic interaction motifs (RHIM) play a key role in cell death and inflammatory si...

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Publicado no:Nat Microbiol
Main Authors: Pearson, Jaclyn S., Giogha, Cristina, Mühlen, Sabrina, Nachbur, Ueli, Pham, Chi L. L., Zhang, Ying, Hildebrand, Joanne M., Oates, Clare V., Lung, Tania Wong Fok, Ingle, Danielle, Dagley, Laura F., Bankovacki, Aleksandra, Petrie, Emma J., Schroeder, Gunnar N., Crepin, Valerie F., Frankel, Gad, Masters, Seth L., Vince, James, Murphy, James M., Sunde, Margaret, Webb, Andrew I., Silke, John, Hartland, Elizabeth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613272/
https://ncbi.nlm.nih.gov/pubmed/28085133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2016.258
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