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Somatic mutation: What shapes the mutational landscape of normal epithelia?
Epithelial stem cells accumulate mutations throughout life. Some of these mutants increase competitive fitness and may form clones that colonize the stem cell niche and persist to acquire further genome alterations. After a transient expansion, mutant stem cells must revert to homeostatic behavior s...
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| Publicado no: | Cancer Discov |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2022
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7613026/ https://ncbi.nlm.nih.gov/pubmed/35397477 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-22-0145 |
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