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Somatic mutation: What shapes the mutational landscape of normal epithelia?

Epithelial stem cells accumulate mutations throughout life. Some of these mutants increase competitive fitness and may form clones that colonize the stem cell niche and persist to acquire further genome alterations. After a transient expansion, mutant stem cells must revert to homeostatic behavior s...

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Bibliografiska uppgifter
I publikationen:Cancer Discov
Huvudupphovsmän: Fowler, Joanna C, Jones, Philip H
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2022
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7613026/
https://ncbi.nlm.nih.gov/pubmed/35397477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-22-0145
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