Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium

During aging progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues including the esophageal epithelium (EE) become a patchwork of mutant clones. Despite their relevance for understanding aging and cancer, the processes...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Colom, Bartomeu, Alcolea, Maria P, Piedrafita, Gabriel, Hall, Michael WJ, Wabik, Agnieszka, Dentro, Stefan C, Fowler, Joanna C, Herms, Albert, King, Charlotte, Ong, Swee Hoe, Sood, Roshan K, Gerstung, Moritz, Martincorena, Inigo, Hall, Benjamin A, Jones, Philip H
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116672/
https://ncbi.nlm.nih.gov/pubmed/32424351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0624-3
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