Mutant clones in normal epithelium outcompete and eliminate emerging tumors

Human epithelial tissues accumulate cancer-driver mutations with age(1–9), yet tumor formation remains rare. The positive selection of these mutations argues they alter the behavior and fitness of proliferating cells(10–12). Hence, normal adult tissues become a patchwork of mutant clones competing f...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Colom, B., Herms, A., Hall, M.W.J., Dentro, S.C., King, C., Sood, R.K., Alcolea, M.P., Piedrafita, G., Fernandez-Antoran, D., Ong, S.H., Fowler, J.C., Mahbubani, K.T., Saeb-Parsy, K., Gerstung, M., Hall, B.A., Jones, P.H.
Format: Artigo
Langue:Inglês
Publié: 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612642/
https://ncbi.nlm.nih.gov/pubmed/34646013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03965-7
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