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Mutant clones in normal epithelium outcompete and eliminate emerging tumors
Human epithelial tissues accumulate cancer-driver mutations with age(1–9), yet tumor formation remains rare. The positive selection of these mutations argues they alter the behavior and fitness of proliferating cells(10–12). Hence, normal adult tissues become a patchwork of mutant clones competing f...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612642/ https://ncbi.nlm.nih.gov/pubmed/34646013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03965-7 |
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