Selection of oncogenic mutant clones in normal human skin varies with body site

Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by location. The prevalence of NOTCH1 and FAT1 mutations in forearm, trunk...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Discov
Prif Awduron: Fowler, Joanna C, King, Charlotte, Bryant, Christopher, Hall, Michael, Sood, Roshan, Ong, Swee Hoe, Earp, Eleanor, Fernandez-Antoran, David, Koeppel, Jonas, Dentro, Stefan C, Shorthouse, David, Durrani, Amer, Fife, Kate, Rytina, Edward, Milne, Doreen, Roshan, Amit, Mahububani, Krishnaa, Saeb-Parsy, Kourosh, Hall, Benjamin A, Gerstung, Moritz, Jones, Philip H
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116717/
https://ncbi.nlm.nih.gov/pubmed/33087317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1092
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg