Selection of oncogenic mutant clones in normal human skin varies with body site

Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high and low risk sites. The density of mutations varied by location. The prevalence of NOTCH1 and FAT1 mutations in forearm, trunk...

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Библиографические подробности
Опубликовано в: :Cancer Discov
Главные авторы: Fowler, Joanna C, King, Charlotte, Bryant, Christopher, Hall, Michael, Sood, Roshan, Ong, Swee Hoe, Earp, Eleanor, Fernandez-Antoran, David, Koeppel, Jonas, Dentro, Stefan C, Shorthouse, David, Durrani, Amer, Fife, Kate, Rytina, Edward, Milne, Doreen, Roshan, Amit, Mahububani, Krishnaa, Saeb-Parsy, Kourosh, Hall, Benjamin A, Gerstung, Moritz, Jones, Philip H
Формат: Artigo
Язык:Inglês
Опубликовано: 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116717/
https://ncbi.nlm.nih.gov/pubmed/33087317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-1092
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