Targeting TLR4 during vaccination boosts MAdCAM-1(+) lymphoid stromal cell activation and promotes the aged germinal center response

The failure to generate enduring humoral immunity after vaccination is a hallmark of advancing age. This can be attributed to a reduction in the germinal center (GC) response, which generates long-lived antibody-secreting cells that protect against (re)infection. Despite intensive investigation, the...

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Publicado en:Sci Immunol
Autores principales: Denton, Alice E, Dooley, James, Cinti, Isabella, Silva-Cayetano, Alyssa, Fra-Bido, Sigrid, Innocentin, Silvia, Hill, Danika L, Carr, Edward J, McKenzie, Andrew NJ, Liston, Adrian, Linterman, Michelle A
Formato: Artigo
Lenguaje:Inglês
Publicado: 2022
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612953/
https://ncbi.nlm.nih.gov/pubmed/35522725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abk0018
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