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The CC′ and DE Loops in Ig Domains 1 and 2 of MAdCAM-1 Play Different Roles in MAdCAM-1 Binding to Low- and High-affinity Integrin α(4)β(7)
Lymphocyte homing is regulated by the dynamic interaction between integrins and their ligands. Integrin α(4)β(7) mediates both rolling and firm adhesion of lymphocytes by modulating its affinity to the ligand, mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Although previous studies have reve...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069412/ https://ncbi.nlm.nih.gov/pubmed/21296888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.208900 |
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