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CRISPR/Cas9-Mediated Introduction of Specific Heterozygous Mutations in Human Induced Pluripotent Stem Cells

Advances in genome editing and our ability to derive and differentiate human induced pluripotent stem cells (hiPSCs) into a wide variety of cell types present in the body is revolutionizing how we model human diseases in vitro. Central to this has been the development of the CRISPR/Cas9 system as an...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Brandão, Karina O., Grandela, Catarina, Yiangou, Loukia, Mummery, Christine L., Davis, Richard P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612905/
https://ncbi.nlm.nih.gov/pubmed/33755904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/7651_2021_368
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