Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome

Kinetochores assemble onto specialized centromeric CENP-A nucleosomes (CENP-A(Nuc)) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-EM structures of the human inner kinetochore CCAN (Constitutive Centromere Associated Network) complex bound to CENP-A(Nuc) reconst...

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Publicado en:Science
Main Authors: Yatskevich, Stanislau, Muir, Kyle W., Bellini, Dom, Zhang, Ziguo, Yang, Jing, Tischer, Thomas, Predin, Masa, Dendooven, Tom, McLaughlin, Stephen H., Barford, David
Formato: Artigo
Idioma:Inglês
Publicado: 2022
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612757/
https://ncbi.nlm.nih.gov/pubmed/35420891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abn3810
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