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Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N
Accurate chromosome segregation requires the proper assembly of kinetochore proteins. A key step in this process is the recognition of the histone H3 variant CENP-A in the centromeric nucleosome by the kinetochore protein CENP-N. We report cryo–electron microscopy (cryo-EM), biophysical, biochemical...
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Publicado no: | Science |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6292214/ https://ncbi.nlm.nih.gov/pubmed/29269420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aar2781 |
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