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Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome
Kinetochores assemble onto specialized centromeric CENP-A nucleosomes (CENP-A(Nuc)) to mediate attachments between chromosomes and the mitotic spindle. We describe cryo-EM structures of the human inner kinetochore CCAN (Constitutive Centromere Associated Network) complex bound to CENP-A(Nuc) reconst...
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| Pubblicato in: | Science |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2022
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612757/ https://ncbi.nlm.nih.gov/pubmed/35420891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abn3810 |
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