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Structure of pathological TDP-43 filaments from ALS with FTLD
The abnormal aggregation of transactive response DNA-binding protein of 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)( 1,2 ). It is also common...
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| Izdano u: | Nature |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2022
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7612255/ https://ncbi.nlm.nih.gov/pubmed/34880495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-04199-3 |
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