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Structure of pathological TDP-43 filaments from ALS with FTLD

The abnormal aggregation of transactive response DNA-binding protein of 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)( 1,2 ). It is also common...

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Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Arseni, Diana, Hasegawa, Masato, Murzin, Alexey G., Kametani, Fuyuki, Arai, Makoto, Yoshida, Mari, Ryskeldi-Falcon, Benjamin
Format: Artigo
Sprog:Inglês
Udgivet: 2022
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612255/
https://ncbi.nlm.nih.gov/pubmed/34880495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-04199-3
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