Endogenous T-cell receptor promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated T-cell receptor knockout CAR

Anti-CD19 chimeric antigen receptor (CAR) T cells showed significant anti-leukemic activity in B-precursor acute lymphoblastic leukemia (ALL). Allogeneic, HLA-mismatched off-the-shelf 3(rd)-party donors may offer ideal fitness of the effector cells but carry the risk of graft-versus-host disease. Kn...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Stenger, Dana, Stief, Tanja A., Kaeuferle, Theresa, Willier, Semjon, Rataj, Felicitas, Schober, Kilian, Vick, Binje, Lotfi, Ramin, Wagner, Beate, Grünewald, Thomas G. P., Kobold, Sebastian, Busch, Dirk H., Jeremias, Irmela, Blaeschke, Franziska, Feuchtinger, Tobias
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612202/
https://ncbi.nlm.nih.gov/pubmed/32483603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005185
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