Endogenous T-cell receptor promotes in vivo persistence of CD19-CAR-T cells compared to a CRISPR/Cas9-mediated T-cell receptor knockout CAR

Anti-CD19 chimeric antigen receptor (CAR) T cells showed significant anti-leukemic activity in B-precursor acute lymphoblastic leukemia (ALL). Allogeneic, HLA-mismatched off-the-shelf 3(rd)-party donors may offer ideal fitness of the effector cells but carry the risk of graft-versus-host disease. Kn...

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Detaylı Bibliyografya
Yayımlandı:Blood
Asıl Yazarlar: Stenger, Dana, Stief, Tanja A., Kaeuferle, Theresa, Willier, Semjon, Rataj, Felicitas, Schober, Kilian, Vick, Binje, Lotfi, Ramin, Wagner, Beate, Grünewald, Thomas G. P., Kobold, Sebastian, Busch, Dirk H., Jeremias, Irmela, Blaeschke, Franziska, Feuchtinger, Tobias
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7612202/
https://ncbi.nlm.nih.gov/pubmed/32483603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005185
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