CRISPR-Cas9-Mediated Glucocorticoid Resistance in Virus-Specific T Cells for Adoptive T Cell Therapy Posttransplantation

Immunosuppression posttransplantation exposes patients to an increased risk for refractory viral infections as an important cause of morbidity and mortality. Protective T cell immunity can be restored by adoptive T cell transfer, but ongoing immunosuppression limits efficacy of T cell responses. In...

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Publicat a:Mol Ther
Autors principals: Kaeuferle, Theresa, Deisenberger, Larissa, Jablonowski, Lena, Stief, Tanja A., Blaeschke, Franziska, Willier, Semjon, Feuchtinger, Tobias
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2020
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474265/
https://ncbi.nlm.nih.gov/pubmed/32559432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.06.002
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