Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

Genetic recombination arises during meiosis via repair of DNA double-strand breaks (DSBs) created by the topoisomerase-like Spo11 protein(1,2). Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots(3,4), yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nature
Main Authors: Johnson, Dominic, Crawford, Margaret, Cooper, Tim, Bouuaert, Corentin Claeys, Keeney, Scott, Llorente, Bertrand, Garcia, Valerie, Neale, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611867/
https://ncbi.nlm.nih.gov/pubmed/34108687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03389-3
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker