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Concerted cutting by Spo11 illuminates meiotic DNA break mechanics
Genetic recombination arises during meiosis via repair of DNA double-strand breaks (DSBs) created by the topoisomerase-like Spo11 protein(1,2). Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots(3,4), yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is...
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| Publicado no: | Nature |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611867/ https://ncbi.nlm.nih.gov/pubmed/34108687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03389-3 |
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