Concerted cutting by Spo11 illuminates meiotic DNA break mechanics

Genetic recombination arises during meiosis via repair of DNA double-strand breaks (DSBs) created by the topoisomerase-like Spo11 protein(1,2). Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots(3,4), yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is...

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Publicat a:Nature
Autors principals: Johnson, Dominic, Crawford, Margaret, Cooper, Tim, Bouuaert, Corentin Claeys, Keeney, Scott, Llorente, Bertrand, Garcia, Valerie, Neale, Matthew J.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611867/
https://ncbi.nlm.nih.gov/pubmed/34108687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03389-3
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