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Concerted cutting by Spo11 illuminates meiotic DNA break mechanics
Genetic recombination arises during meiosis via repair of DNA double-strand breaks (DSBs) created by the topoisomerase-like Spo11 protein(1,2). Spo11 DSBs form preferentially in nucleosome-depleted regions termed hotspots(3,4), yet how Spo11 engages with its DNA substrate to catalyse DNA cleavage is...
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| 出版年: | Nature |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7611867/ https://ncbi.nlm.nih.gov/pubmed/34108687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-021-03389-3 |
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