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Systematic refinement of gene annotations by parsing mRNA 3′ end sequencing datasets

Alternative cleavage and polyadenylation generates mRNA 3′ isoforms in a cell type-specific manner. Due to finite available RNA sequencing data of organisms with vast cell type complexity, currently available gene annotation resources are incomplete, which poses significant challenges to the compreh...

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Detalhes bibliográficos
Publicado no:Methods Enzymol
Main Authors: Bhat, Pooja, Burkard, Thomas R., Herzog, Veronika A., Pauli, Andrea, Ameres, Stefan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7611212/
https://ncbi.nlm.nih.gov/pubmed/34183122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2021.03.016
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