Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

Alpha-synuclein (α-syn) fibrils, a major constituent of the neurotoxic Lewy Bodies in Parkinson’s disease, form via nucleation dependent polymerization and can replicate by a seeding mechanism. Brazilin, a small molecule derived from red cedarwood trees in Brazil, has been shown to inhibit the fibri...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Nahass, George R., Sun, Yuanzi, Xu, Yong, Batchelor, Mark, Reilly, Madeleine, Benilova, Iryna, Kedia, Niraja, Spehar, Kevin, Sobott, Frank, Sessions, Richard B., Caughey, Byron, Radford, Sheena E., Jat, Parmjit, Collinge, John, Bieschke, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610480/
https://ncbi.nlm.nih.gov/pubmed/33610557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166878
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