Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells, animals, and patients. We reasoned that similar t...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kedia, Niraja, Arhzaouy, Khalid, Pittman, Sara K., Sun, Yuanzi, Batchelor, Mark, Weihl, Conrad C., Bieschke, Jan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2019
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708308/
https://ncbi.nlm.nih.gov/pubmed/31371504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908263116
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