Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

Pathological aggregation of the protein tau into insoluble aggregates is a hallmark of neurodegenerative diseases. The emergence of disease-specific tau aggregate structures termed tau strains, however, remains elusive. Here we show that full-length tau protein can be aggregated in the absence of co...

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Udgivet i:Nat Commun
Main Authors: Chakraborty, Pijush, Rivière, Gwladys, Liu, Shu, de Opakua, Alain Ibáñez, Dervişoğlu, Rıza, Hebestreit, Alina, Andreas, Loren B., Vorberg, Ina M., Zweckstetter, Markus
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270918/
https://ncbi.nlm.nih.gov/pubmed/34244499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24362-8
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