Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

Alpha-synuclein (α-syn) fibrils, a major constituent of the neurotoxic Lewy Bodies in Parkinson’s disease, form via nucleation dependent polymerization and can replicate by a seeding mechanism. Brazilin, a small molecule derived from red cedarwood trees in Brazil, has been shown to inhibit the fibri...

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Pubblicato in:J Mol Biol
Autori principali: Nahass, George R., Sun, Yuanzi, Xu, Yong, Batchelor, Mark, Reilly, Madeleine, Benilova, Iryna, Kedia, Niraja, Spehar, Kevin, Sobott, Frank, Sessions, Richard B., Caughey, Byron, Radford, Sheena E., Jat, Parmjit, Collinge, John, Bieschke, Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610480/
https://ncbi.nlm.nih.gov/pubmed/33610557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2021.166878
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