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Super-Resolution Imaging of Amyloid Structures over Extended Times Using Transient Binding of Single Thioflavin T Molecules

Oligomeric amyloid structures are crucial therapeutic targets in Alzheimer’s and other amyloid diseases. However, these oligomers are too small to be resolved by standard light microscopy. We have developed a simple and versatile tool to image amyloid structures using Thioflavin T without the need f...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Spehar, Kevin, Ding, Tianben, Sun, Yuanzi, Kedia, Niraja, Lu, Jin, Nahass, George R., Lew, Matthew D., Bieschke, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6428420/
https://ncbi.nlm.nih.gov/pubmed/29953718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800352
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