Apolipoprotein E isoforms differentially regulate matrix metallopeptidase 9 function in Alzheimer’s disease

Apolipoprotein E (APOE) has been shown to influence amyloid-β (Aβ) clearance from the brain in an isoform-specific manner. Our prior work showed Aβ transit across the blood-brain-barrier was reduced by apoE4, compared to other apoE isoforms, due to elevated lipoprotein receptor shedding in brain end...

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Veröffentlicht in:Neurobiol Aging
Hauptverfasser: Ringland, Charis, Schweig, Jonas Elias, Paris, Daniel, Shackleton, Ben, Lynch, Cillian E., Eisenbaum, Maxwell, Mullan, Michael, Crawford, Fiona, Abdullah, Laila, Bachmeier, Corbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609500/
https://ncbi.nlm.nih.gov/pubmed/32758917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.06.018
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