The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1: Implications for Immunotherapy Treatment

Programmed death-ligand 1 (PD-L1) is an immune checkpoint inhibitor that binds to its receptor PD-1 expressed by T cells and other immune cells to regulate immune responses; ultimately preventing exacerbated activation and autoimmunity. Many tumors exploit this mechanism by overexpressing PD-L1 whic...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Hudson, Katie, Cross, Neil, Jordan-Mahy, Nicola, Leyland, Rebecca
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609400/
https://ncbi.nlm.nih.gov/pubmed/33193345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.568931
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