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The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1: Implications for Immunotherapy Treatment

Programmed death-ligand 1 (PD-L1) is an immune checkpoint inhibitor that binds to its receptor PD-1 expressed by T cells and other immune cells to regulate immune responses; ultimately preventing exacerbated activation and autoimmunity. Many tumors exploit this mechanism by overexpressing PD-L1 whic...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Hudson, Katie, Cross, Neil, Jordan-Mahy, Nicola, Leyland, Rebecca
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7609400/
https://ncbi.nlm.nih.gov/pubmed/33193345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.568931
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