Early Carcinogenesis Involves the Establishment of Immune Privilege via Intrinsic and Extrinsic Regulation of Indoleamine 2,3-dioxygenase-1: Translational Implications in Cancer Immunotherapy

Although prolonged genetic pressure has been conjectured to be necessary for the eventual development of tumor immune evasion mechanisms, recent work is demonstrating that early genetic mutations are capable of moonlighting as both intrinsic and extrinsic modulators of the tumor immune microenvironm...

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Detalhes bibliográficos
Main Authors: Holtzhausen, Alisha, Zhao, Fei, Evans, Kathy S., Hanks, Brent A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186479/
https://ncbi.nlm.nih.gov/pubmed/25339948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2014.00438
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