Noncoding RNA transcription alters chromosomal topology to promote isotype-specific class switch recombination

B cells undergo two types of genomic alterations to increase antibody diversity: introduction of point mutations into immunoglobulin heavy- and light-chain (IgH and IgL) variable regions by somatic hypermutation (SHM) and alteration of antibody effector functions by changing the expressed IgH consta...

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Pubblicato in:Sci Immunol
Autori principali: Rothschild, Gerson, Zhang, Wanwei, Lim, Junghyun, Giri, Pankaj Kumar, Laffleur, Brice, Chen, Yiyun, Fang, Mingyan, Chen, Yuling, Nair, Lekha, Liu, Zhi-Ping, Deng, Haiteng, Hammarström, Lennart, Wang, Jiguang, Basu, Uttiya
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608691/
https://ncbi.nlm.nih.gov/pubmed/32034089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aay5864
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