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Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages, replicates inside them, and leads to their death, releasing Mtb that can infect other cells. We found that the death of Mtb-infected...

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Détails bibliographiques
Publié dans:J Exp Med
Auteurs principaux: Zhang, Li, Jiang, Xiuju, Pfau, Daniel, Ling, Yan, Nathan, Carl F.
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608065/
https://ncbi.nlm.nih.gov/pubmed/33125053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200887
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