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Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages, replicates inside them, and leads to their death, releasing Mtb that can infect other cells. We found that the death of Mtb-infected...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Zhang, Li, Jiang, Xiuju, Pfau, Daniel, Ling, Yan, Nathan, Carl F.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608065/
https://ncbi.nlm.nih.gov/pubmed/33125053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200887
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