Type I interferon signaling mediates Mycobacterium tuberculosis–induced macrophage death

Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major cause of tuberculosis (TB). Once phagocytized, Mtb resists killing by macrophages, replicates inside them, and leads to their death, releasing Mtb that can infect other cells. We found that the death of Mtb-infected...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Zhang, Li, Jiang, Xiuju, Pfau, Daniel, Ling, Yan, Nathan, Carl F.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2020
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7608065/
https://ncbi.nlm.nih.gov/pubmed/33125053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200887
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