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Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling

OBJECTIVES: Autophagy is divided into three phases: autophagosome engulfment of intracellular organelles and proteins, autophagosome fusion with lysosomes, and autolysosome degradation. The farnesyl pyrophosphate synthase inhibitor ibandronate (IBAN) has in vivo cardioprotective properties, potentia...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Int Med Res
Prif Awduron: Han, Jie, Huang, Chaoyang, Jiang, Jiukun, Jiang, Dongmei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: SAGE Publications 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7607048/
https://ncbi.nlm.nih.gov/pubmed/31884848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0300060519875371
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