Inhibition of Protein Tyrosine Phosphatase Receptor Type F Suppresses Wnt Signaling in Colorectal Cancer

Wnt signaling dysregulation promotes tumorigenesis in colorectal cancer (CRC). We investigated the role of PTPRF, a receptor-type tyrosine phosphatase, in regulating Wnt signaling in CRC. Knockdown of PTPRF decreased cell proliferation in patient-derived primary colon cancer cells and established CR...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Gan, Tong, Stevens, Ashley T., Xiong, Xiaopeng, Wen, Yang-An, Farmer, Trevor N., Li, Austin T., Stevens, Payton D., Golshani, Sanam, Weiss, Heidi L., Evers, B. Mark, Gao, Tianyan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606795/
https://ncbi.nlm.nih.gov/pubmed/32973331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01472-z
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