Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set out to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC), as its role in immune-silent solid tumors is poorly understood. We demo...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Katkeviciute, Egle, Hering, Larissa, Montalban-Arques, Ana, Busenhart, Philipp, Schwarzfischer, Marlene, Manzini, Roberto, Conde, Javier, Atrott, Kirstin, Lang, Silvia, Rogler, Gerhard, Naschberger, Elisabeth, Schellerer, Vera S., Stürzl, Michael, Rickenbacher, Andreas, Turina, Matthias, Weber, Achim, Leibl, Sebastian, Leventhal, Gabriel E., Levesque, Mitchell, Boyman, Onur, Scharl, Michael, Spalinger, Marianne R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773375/
https://ncbi.nlm.nih.gov/pubmed/33001862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140281
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