Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N(2) in Dendritic Cells to Protect from Elevated Colitis

Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolle...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Hering, Larissa, Katkeviciute, Egle, Schwarzfischer, Marlene, Niechcial, Anna, Riggs, Julianne B., Wawrzyniak, Marcin, Atrott, Kirstin, van de Sande, Marnix, Lang, Silvia, Becher, Burkhard, Rogler, Gerhard, Scharl, Michael, Spalinger, Marianne R.
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269284/
https://ncbi.nlm.nih.gov/pubmed/34201918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136820
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