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Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N(2) in Dendritic Cells to Protect from Elevated Colitis
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) plays a critical role in the pathogenesis of inflammatory bowel diseases (IBD). Mice lacking PTPN2 in dendritic cells (DCs) develop skin and liver inflammation by the age of 22 weeks due to a generalized loss of tolerance leading to uncontrolle...
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| Veröffentlicht in: | Int J Mol Sci |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8269284/ https://ncbi.nlm.nih.gov/pubmed/34201918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136820 |
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