Erbin suppresses KSR1-mediated RAS/RAF signaling and tumorigenesis in colorectal cancer

Erbin belongs to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that plays important roles in orchestrating cell signaling. Here we show that Erbin functions as a tumor suppressor in colorectal cancer (CRC). Analysis of Erbin expression in CRC patient specimens revealed...

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Udgivet i:Cancer Res
Main Authors: Stevens, Payton D., Wen, Yang-An, Xiong, Xiaopeng, Zaytseva, Yekaterina Y., Li, Austin T., Wang, Chi, Stevens, Ashley, Farmer, Trevor N., Gan, Tong, Weiss, Heidi L., Inagaki, Masaki, Marchetto, Sylvie, Borg, Jean-Paul, Gao, Tianyan
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6510240/
https://ncbi.nlm.nih.gov/pubmed/29980571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-3629
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