Kinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway

Background & Aims: Mutations in the RAS and RAF genes are frequently observed in various human cancers, leading to persistent activation of the RAS/RAF/MEK/ERK signaling pathway and driving tumorigenesis. Intriguingly, hepatocellular carcinoma (HCC) reveals rare mutations in RAS and RAF, despite...

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Autori principali:	Hyuk Moon, Hyunjung Park, Sangjik Lee, Soyun Lee, Mihyeon Jun, Jaehun Lee, Jiyeon Baek, Hyerin Park, Jieun Bang, Simon Weonsang Ro
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2025-11-01
Serie:	JHEP Reports
Soggetti:	Kinase suppressor of Ras 1 Hepatocellular carcinoma Hydrodynamic tail vein injection Scaffold protein RAS RAF
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589555925002150
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