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Kinase suppressor of Ras 1 (KSR1) promotes liver carcinogenesis via activation of the RAS/RAF/MEK/ERK signaling pathway

Background & Aims: Mutations in the RAS and RAF genes are frequently observed in various human cancers, leading to persistent activation of the RAS/RAF/MEK/ERK signaling pathway and driving tumorigenesis. Intriguingly, hepatocellular carcinoma (HCC) reveals rare mutations in RAS and RAF, despite...

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Wedi'i Gadw mewn:
Prif Awduron: Hyuk Moon, Hyunjung Park, Sangjik Lee, Soyun Lee, Mihyeon Jun, Jaehun Lee, Jiyeon Baek, Hyerin Park, Jieun Bang, Simon Weonsang Ro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2025-11-01
Cyfres:JHEP Reports
Pynciau:
Kinase suppressor of Ras 1
Hepatocellular carcinoma
Hydrodynamic tail vein injection
Scaffold protein
RAS
RAF
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2589555925002150
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