A 12-Lipoxygenase-Gpr31 signaling axis is required for pancreatic organogenesis in the zebrafish

12-lipoxygenase (12-LOX) is a key enzyme in arachidonic acid metabolism, and alongside its major product, 12-HETE, plays a key role in promoting inflammatory signaling during diabetes pathogenesis. Although 12-LOX is a proposed therapeutic target to protect pancreatic islets in the setting of diabet...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Hernandez-Perez, Marimar, Kulkarni, Abhishek, Samala, Niharika, Sorrell, Cody, El, Kimberly, Haider, Isra, Aleem, Ansari Mukhtar, Holman, Theodore R, Rai, Ganesha, Tersey, Sarah A, Mirmira, Raghavendra G, Anderson, Ryan M
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606739/
https://ncbi.nlm.nih.gov/pubmed/32918516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201902308RR
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