Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in mouse islet β cells

In type 1 diabetes, an autoimmune event increases oxidative stress in islet β cells, giving rise to cellular dysfunction and apoptosis. Lipoxygenases are enzymes that catalyze the oxygenation of polyunsaturated fatty acids that can form lipid metabolites involved in several biological functions, inc...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Conteh, Abass M., Reissaus, Christopher A., Hernandez-Perez, Marimar, Nakshatri, Swetha, Anderson, Ryan M., Mirmira, Raghavendra G., Tersey, Sarah A., Linnemann, Amelia K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Lipids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484126/
https://ncbi.nlm.nih.gov/pubmed/30792307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007102
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