Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis

Nairoviruses are arthropod-borne viruses with a nearly global geographical distribution. Several are known causative agents of human disease, including Crimean–Congo hemorrhagic fever virus (CCHFV), which has a case fatality rate that can exceed 30%. Nairoviruses encode an ovarian tumour domain prot...

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Bibliographic Details
Published in:Acta Crystallogr D Struct Biol
Main Authors: Dzimianski, John V., Mace, Savannah L., Williams, Isabelle L., Freitas, Brendan T., Pegan, Scott D.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2020
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604911/
https://ncbi.nlm.nih.gov/pubmed/33135682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798320012875
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