Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases

Tick-borne nairoviruses (order Bunyavirales) encode an ovarian tumor domain protease (OTU) that suppresses the innate immune response by reversing the post-translational modification of proteins by ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15). Ub is highly conserved across eukary...

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Udgivet i:PLoS One
Main Authors: Dzimianski, John V., Scholte, Florine E. M., Williams, Isabelle L., Langley, Caroline, Freitas, Brendan T., Spengler, Jessica R., Bergeron, Éric, Pegan, Scott D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927636/
https://ncbi.nlm.nih.gov/pubmed/31869347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226415
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