Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY) of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In this study we present a detailed contribution of...

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Publicat a:Haematologica
Autors principals: Graça, Nuno A. G., Ercig, Bogac, Pereira, Leydi Carolina Velásquez, Kangro, Kadri, Kaijen, Paul, Nicolaes, Gerry A. F., Veyradier, Agnès, Coppo, Paul, Vanhoorelbeke, Karen, Männik, Andres, Voorberg, Jan
Format: Artigo
Idioma:Inglês
Publicat: Fondazione Ferrata Storti 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604655/
https://ncbi.nlm.nih.gov/pubmed/33131251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.226068
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